PAN-Seratech offers a broad range of high quality serum replacements. You can find more information on the appropriate sites.
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Serum introduces several severe unknown variables into the cell culture procedure, as serum (a) is a poorly defined supplement (Bjare, 1992; Gstraunthaler, 2003); (b) batches show typically qualitative variations and different amount of endotoxins, haemoglobin and other factors (Price and Gregory, 1982); (c) can be a potential source of contamination (Dormont, 1999; Eliot, 1999; Wessman and Levings, 1999) and (d) does not represent physiological conditions. Therefore, FBS may alter the experimental output or the performance of assays.